11th International Veterinary Congress
University of Tehran, Iran
Title: Study effects of ivermectin and interaction with supplements vitamin A and vitamin C on oxidative stress system in male wistar rat
Biography: Alireza Bashiri
For an in vivo investigation a total of 25 male Wistar rats of 6-8 weeks old and 150-200g, were equally divided into five experimental groups; control group; oral solution of ivermectin; mixture of ivermectin and vitamin A; mixture of ivermectin and vitamin C; mixture of ivermectin, vitamin A and vitamin C; weekly for three weeks. At the end of the experimentation, the rats were sacrificed and measurements of the oxidative stress factors were done. The results of the study showed that the administration of free ivermectin orally led to serum oxidative stress. However, the use of vitamin A and vitamin C might have a promising effect against stress oxidative duo to usage of the drug. The administration of free ivermectin has side effects on mammals, while use of the drug supplemented with antioxidants like vitamin A and vitamin C moderates its toxic effects.