University of Tehran, Iran
Title: Study effects of ivermectin and interaction with supplements vitamin A and vitamin C on histological structure of the liver, kidney, and testis tissue in male wistar rat
Biography: Alireza Bashiri
An in vivo study was performed to assay the effects of ivermectin on adult male Wistar rats. Twenty-five male Wistar rats of 6-8 weeks old and 150-200 g, divided into five groups of five animals each were used for this study. Group’s two to five received drug oral solution of ivermectin; mixture of ivermectin and vitamin A; mixture of ivermectin and vitamin C; mixture of ivermectin, vitamin A and vitamin C respectively. The treatment was performed once a week for three weeks. Group one served as the control group. At the end of the study, the rats were sacrificed and histopathological studies on liver, kidney and scrotal tissues were done. The results of this study showed that administration of free ivermectin orally causes pathological changes in the liver, kidney and scrotal tissue, including congestion and necrosis and usage of vitamin A and vitamin C as anti-oxidants improved the obtained situation of the taking free ivermectin. It can be concluded that consumption of free ivermectin has side effects on mammals, while use of the drug along with antioxidants like vitamin A and vitamin C moderate its toxic effects.